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Numerous unpublished studies submitted to the Food and Drug Administration by pharmaceutical companies have found that many popular antidepressants have little or no effect on patients, according to a new review of the previously hidden findings.

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Since the overwhelming amount of published data on the drugs show they are effective, doctors unaware of the unpublished data are making inappropriate prescribing decisions that are not in the best interest of their patients, according to researchers led by Erick Turner, a psychiatrist at Oregon Health and Science University. Sales of antidepressants total about $21 billion a year, according to IMS Health.